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邱菊

邱菊

博士
炎癥與免疫調節(jié)研究組組長

郵箱: qiuju@sinh.ac.cn

電話: +86-21-54923301

所屬部門: 中國科學院腫瘤與微環(huán)境重點實驗室

個人簡歷

2017-至　 今：中國科學院上海營養(yǎng)與健康研究所 研究員
2014-2016年：中國科學院上海生命科學研究院/上海交通大學醫(yī)學院 健康科學研究所 研究員
2009-2014年：西北大學Feinberg醫(yī)學院 微生物與免疫學系 博士后
2009.04-2009.11：愛因斯坦醫(yī)學院 細胞生物學系 博士后
2004-2009年：上海交通大學醫(yī)學院 免疫學 醫(yī)學博士
1999-2004年：泰山醫(yī)學院（現(xiàn)山東第一醫(yī)科大學）臨床醫(yī)學 學士

研究方向

粘膜免疫與天然淋巴細胞

研究內容

天然淋巴細胞（Innate lymphoid cells, ILC）是一群譜系陰性（Lin-）、缺乏T、B細胞抗原特異性受體的天然免疫細胞亞群。ILC廣泛存在于多種器官及粘膜組織，在感染性疾病、過敏性疾病、自身免疫病及腫瘤中發(fā)揮重要作用。我們利用炎癥性疾病模型、細胞過繼轉移、細胞體外分化、多色流式及生物信息學等手段，主要研究調控ILC2和ILC3發(fā)育和功能的分子機制及對炎癥性疾病的影響，以為診斷或治療炎癥性疾病提供理論依據(jù)和新手段。

代表論著（#第一作者，*通訊作者）

  1. Jupei Tang#, Hanxiao Sun#, Huidan Chang, Liyun Yuan, Yue Chen, Xueliang Zhang, Yongzhen Tao, Lifeng Yang, Zhen Shao, Xiaohuan Guo, Hong Zhou, Huiming Sheng, Qiang Zou, Xiao Su, Jinxin Qiu*, Jun Qin*, Ju Qiu*. Brg1-imprinted chromatin status controls the effector and memory ILC2 metabolism to exacerbate allergic lung inflammation. J Allergy Clin Immunol 2025 Sep 17:S0091-6749(25)00948-0. doi: 10.1016/j.jaci.2025.08.029
  2. Hanxiao Sun, Jinxin Qiu*, Ju Qiu*. Epigenetic regulation of innate lymphoid cells. Eur J Immunol 2024 Sep;54(9):e2350379 (invited review)
  3. Hanxiao Sun, Jie Shu, Jupei Tang, Yue Li, Jinxin Qiu, Zhaoyun Ding, Binbin Xuan, Minghui Chen, Chenxin Gan, Jinpiao Lin, Ju Qiu*, Huiming Sheng*, Chuanxin Wang*. GLP-1 receptor agonists alleviate colonic inflammation by modulating intestinal microbiota and the function of group 3 innate lymphoid cells. Immunology 2024 Jul;172(3):451-468
  4. Zhaoyun Ding#, Ting Cai#, Jupei Tang, Hanxiao Sun, Xinyi Qi, Yunpeng Zhang, Yan Ji, Liyun Yuan, Huidan Chang, Yanhui Ma, Hong Zhou, Li Li*, Huiming Sheng*, Ju Qiu*. Setd2 supports GATA3+ST2+ thymic-derived Treg cells and suppresses intestinal inflammation. Nat Commun 2022 Dec 3;13(1):7468
  5. Zhao Li#, Hanxiao Sun#, Zhitao Gu*, Ju Qiu*. Emerging roles of ILC2s in antitumor immunity. Cell Mol Immunol 2022 Nov;19(11):1311-1313
  6. Jinxin Qiu, Yanhui Ma*, Ju Qiu*. Regulation of intestinal immunity by dietary fatty acids. Mucosal Immunol 2022 May;15(5):846-856
  7. Jiali Chang, Xiaojuan Ji, Tian Deng, Jinxin Qiu, Zhaoyun Ding, Zhao Li, Yanhui Ma, Xiaoyu Hu, Li Li*, Ju Qiu*. Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity. Cell Rep 2022 Mar 15;38(11):110530
  8. Jingjing Zhang#, Jinxin Qiu#, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He*, Ju Qiu*, Lei Shen*. Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity. Nat Immunol 2022 Feb;23(2):237-250
  9. Qiu J#, Zhang J#, Ji Y*, Sun H#, Gu Z, Sun Q, Bai M, Gong J, Tang J, Zhang Y, Li S, Shao Z, Li J, Sheng H*, Shen L*, Qiu J*. Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity. Mucosal Immunol 2021 Nov;14(6):1306-1322
  10. Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, Sun L, Chai Q, Qin J*, Qiu J*. Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity. Mucosal Immunol 2021 Jan;14(1):38-52
  11. Deng T, Suo C, Chang J, Yang R, Li J, Cai T, Qiu J*. ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice. Cell Mol Immunol 2020 Feb;17(2):163-177
  12. Li J#, Shi W#, Sun H, Ji Y, Chen Y, Guo X, Sheng H, Shu J, Zhou L, Cai T, Qiu J*. Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation. Nat Commun 2019 Jul 29;10(1):3371
  13. Ting Cai#, Jinxin Qiu#, Yan Ji, Wenjing Li, Zhaoyun Ding, Caixia Suo, Jiali Chang, Jingjing Wang, Rui He, Youcun Qian, Xiaohuan Guo, Liang Zhou, Huiming Sheng*, Lei Shen*, Ju Qiu*. IL-17-producing-ST2+ILC2 plays a pathogenic role in lung inflammation. J Allergy Clin Immunol 2019 Jan;143(1):229-244
  14. Ye J#, Qiu J#, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L. The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells. Cell Rep 2017 Nov 21;21(8):2277-2290
  15. Suo C, Fan Z, Zhou L, Qiu J*. Perfluorooctane sulfonate affects intestinal immunity against bacterial infection. Sci Rep 2017 Jul 12;7(1):5166
  16. Ruomeng Qiu, Wenli Shi, Ting Cai, Siyu Pei, Ting Tang, Yafei Huang, Huan Wang, Liming Shao, Ju Qiu*, Yonghui Wang*. Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression. Med Chem Commun 2016;7(12):2344-2348
  17. Qiu J, Zhou L. Aryl hydrocarbon receptor promotes RORγt(+) group 3 ILCs and controls intestinal immunity and inflammation. Semin Immunopathol 2013 Nov;35(6):657-670
  18. Qiu J, Guo X, Chen ZM, He L, Sonnenberg GF, Artis D, Fu YX, Zhou L. Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 2013 Aug 22;39(2):386-399
  19. Qiu J, Heller JJ, Guo X, Chen ZM, Fish K, Fu YX, Zhou L. The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity 2012 Jan 27;36(1):92-104
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