caopornx在线超碰免费-欧美亚洲性色影视在线-人妻无码AV一区二区三区-欧美日韩国产一区二区三区播放-青青草原精品国产亚洲AV-日本黄A级A片国产免费-亚洲精品一区久久久久久-成人18禁在线WWW免费视频

龍凌云

龍凌云

博士
細胞免疫與疾病干預研究組組長

郵箱: lylong@sinh.ac.cn

電話: +86-21-54920721

所屬部門: 中國科學院腫瘤與微環(huán)境重點實驗室

個人簡歷

2022.09-至  ?今:中國科學院上海營養(yǎng)與健康研究所 研究員
2022.01-2022.08:St. Jude Children's Research Hospital 資深科學家
2014.12-2022.01:St. Jude Children's Research Hospital 博士后
2013.08-2014.07:中國科學院上海生命科學研究院營養(yǎng)科學研究所 研究助理
2006.09-2013.07:中國科學院上海生命科學研究院 博士
2002.09-2006.06:武漢大學生命科學學院 學士

研究方向

T細胞分化和功能調(diào)控

研究內(nèi)容

綜合應用CRISPR篩選、單細胞RNA測序等系統(tǒng)生物學手段和常規(guī)生物化學方法,結(jié)合小鼠疾病模型和臨床病人樣品來研究T細胞的分化和功能在腫瘤、自身免疫性疾病、過敏性炎癥和代謝性疾病(例如糖尿?。┑炔±項l件下如何被精細調(diào)控;并據(jù)此開發(fā)新的治療靶點和疾病干預策略。

代表論著(#第一作者,*通訊作者)

1.?Liu Z., Zhang Y., Ma N., Yang Y., Ma Y., Wang F., Wang Y., Wei J., Chen H., Tartarone A., Velotta J. B., Dayyani F., Gabriel E., Wakefield C. J., Kidane B., Carbonelli C., Long L.*, Liu Z.*, Su J.*, Li Z*. (2023) Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma. Cancer Cell 41 (11), 1852-1870. e9 (* co-corresponding author)

2.?Xia J., Ma N., Shi Q., Liu Q. C., Zhang W., Cao H. J., Wang Y. K., Zheng Q. W., Ni Q. J., Xu S., Zhu B., Qiu X. S., Ding K., Huang J. Y., Liang X., Chen Y., Xiang Y. J., Zhang X. R., Qiu L., Chen W., Xie D., Wang X., Long L.*, Li J. J*. (2023) XAF1 promotes colorectal cancer metastasis via VCP–RNF114–JUP axis. Journal of Cell Biology 223 (2), e202303015 (* co-corresponding author)

3.?Long L.#, Wei J., Lim S. A., Raynor J. L., Shi H., Connelly J. P., Wang H., Guy C., Xie B., Chapman N. M., Fu G., Wang Y., Huang H., Su W., Saravia J., Risch I., Wang Y. D., Li Y., Niu M., Dhungana, Y., Kc, A., Zhou, P., Vogel, P., Yu, J., Pruett-Miller, S. M., Peng, J., Chi, H*. (2021) CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Nature 600,308-313

4.?Wei, J.#, Long, L.#, Zheng W., Dhungana, Y., Lim, S. A., Guy, C., Wang, Y., Wang, Y., Qian, C., Xu, B., Kc, A., Saravia, J., Huang, H., Yu, J., Doench, J. G., Geiger, T. L., Chi, H*. (2019) Targeting Regnase-1 programs long-lived effector T cells for cancer therapy. Nature 576(7787):471-476 (# co-first author)

5.?Long, L.#, Deng, Y., Yao, F., Guan, D., Feng, Y., Jiang, H., Li, X., Hu, P., Lu, X., Wang, H., Li, J., Gao, X., Xie, D*. (2014) Recruitment of phosphatase PP2A by RACK1 adaptor protein deactivates transcription factor IRF3 and limits type I interferon signaling. Immunity 40:515-529

6.?Huang, H., Zhou, P., Wei, J., Long, L., Shi, H., Dhungana, Y., Chapman, N. M., Fu, G., Saravia, J., Raynor, J. L., Liu, S., Palacios, G., Wang, Y. D., Qian, C., Yu, J., Chi, H*. (2021) In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions. Cell 2021 Mar 4;184(5):1245-1261.e21

7.?Fu, G., Guy, C. S., Chapman, N. M., Palacios, G., Wei, J., Zhou, P., Long, L., Wang, Y. D., Qian, C., Dhungana, Y., Huang, H., Kc, A., Shi, H., Rankin, S., Brown, S. A., Johnson, A., Wakefield, R., Robinson, C. G., Liu, X., Sheyn, A., Yu, J., Jackowski, S., Chi, H*. (2021) Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine. Nature 2021 Jul;595(7869):724-729

8.?Lim, S. A., Wei, J., Nguyen, T. M., Shi, H., Su, W., Palacios, G., Dhungana, Y., Chapman, N. M., Long, L., Saravia, J., Vogel, P., Chi, H*. (2021) Lipid signalling enforces functional specialization of Treg cells in tumours. Nature 2021 Mar;591(7849):306-311

9.?Zheng, W., Wei, J., Zebley, C., Jones, Long, L., Dhungana, Y., Wang, Y. D., Mavuluri, J., Long, L., Fan, Y., Youngblood, B., Chi, H., Geiger, T. L*. (2021) Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL. Blood 138(2):122-135.

10.?Su, W., Chapman, N. M., Wei, J., Zeng, H., Dhungana, Y., Shi, H., Saravia, J., Zhou, P., Long, L., Rankin, S., Kc, A., Vogel, P., Chi, H*. (2020) Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells. Cell Metab 2020 Dec 1;32(6):996-1011.e7

11.?Huang, H., Long, L., Zhou, P., Chapman, N. M., Chi, H*. (2020) mTOR signaling at the crossroads of environmental signals and T-cell fate decisions. Immunol Rev 2020 May;295(1):15-38

12.?Shi, H., Chapman, N. M., Wen, J., Guy, C., Long, L., Dhungana, Y., Rankin, S., Pelletier, S., Vogel, P., Wang, H., Peng, J., Guan, K. L., Chi, H*. (2019) Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity 2019 Dec 17;51(6):1012-1027.e7

13.?Wang, Y., Du, X., Wei, J., Long, L., Tan, H., Guy, C., Dhungana, Y., Qian, C., Neale, G., Fu, Y. X., Yu, J., Peng, J., Chi, H*. (2019) LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity. Cell Res 2019 May;29(5):391-405

14.?Yang, K., Blanco, D. B., Neale, G., Vogel, P., Avila, J., Clish, C. B., Wu, C., Shrestha, S., Rankin, S., Long, L., Kc, A., Chi, H*. (2017) Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling. Nature 548, 602-606

15.?Karmaus, P. W. F., Herrada, A. A., Guy, C., Neale, G., Dhungana, Y., Long, L., Vogel, P., Avila, J., Clish, C. B., Chi, H*. (2017) Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis. J Exp Med 214, 2629-2647

16.?Li, J. J., Sun, Z. J., Yuan, Y. M., Yin, F. F., Bian, Y. G., Long, L. Y., Zhang, X. L., Xie, D. (2017) EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer. J Biol Chem 292, 1112-1121

17.?Wei, J., Long, L., Yang, K., Guy, C., Shrestha, S., Chen, Z., Wu, C., Vogel, P., Neale, G., Green, D. R., Chi, H*. (2016) Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat Immunol 17, 277-285

18.?Bao, W. D., Fan, Y., Deng, Y. Z., Long, L. Y., Wang, J. J., Guan, D. X., Qian, Z. Y., An, P., Feng, Y. Y., He, Z. Y., Wang, X. F., Phillip Koeffler, H., Hu, R., Wang, J., Wang, X., Wang, F., Li, J. J., Xie, D*. (2016) Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis. J Hepatol 65, 137-145

19.?Guan, D. X., Shi, J., Zhang, Y., Zhao, J. S., Long, L. Y., Chen, T. W., Zhang, E. B., Feng, Y. Y., Bao, W. D., Deng, Y. Z., Qiu, L., Zhang, X. L., Koeffler, H. P., Cheng, S. Q., Li, J. J., Xie, D*. (2015) Sorafenib enriches epithelial cell adhesion molecule-positive tumor initiating cells and exacerbates a subtype of hepatocellular carcinoma through TSC2-AKT cascade. Hepatology 62, 1791-1803

20.?Yao, F., Long, L. Y., Deng, Y. Z., Feng, Y. Y., Ying, G. Y., Bao, W. D., Li, G., Guan, D. X., Zhu, Y. Q., Li, J. J., Xie, D*. (2014) RACK1 modulates NF-kappaB activation by interfering with the interaction between TRAF2 and the IKK complex. Cell Res 24, 359-371

21.?Deng, Y. Z., Yao, F., Li, J. J., Mao, Z. F., Hu, P. T., Long, L. Y., Li, G., Ji, X. D., Shi, S., Guan, D. X., Feng, Y. Y., Cui, L., Li, D. S., Liu, Y., Du, X., Guo, M. Z., Xu, L. Y., Li, E. M., Wang, H. Y., Xie, D*. (2012) RACK1 suppresses gastric tumorigenesis by stabilizing the beta-catenin destruction complex. Gastroenterology 142, 812-823 e815

51久久夜色麻豆精品观后感| 精品农村妇女一二三| 欧美综合精品资源| 亚洲中文字幕二区精品自拍| JIZZ国产精品酒在线观看| 久久精品麻豆国产| 精品国产色约| 蜜臀久久6699精品久久宅男| 精品大长腿一区| 97视频大香蕉精品| 国产精品97超碰大香蕉| 亚洲精品啊啊啊好疼| 尤物精品视频日本一区| 色综合久久夜色精品国产天堂| 中出熟人妻精品| 人妻精品理伦片一区二区三区| 精品国产福利| 蜜臀99久久精品久久久久久软件| 日韩精品一区二区三区电影在线看| 久久精品熟女亚洲av麻豆网站| 少妇高清精品毛片在线视频|