caopornx在线超碰免费-欧美亚洲性色影视在线-人妻无码AV一区二区三区-欧美日韩国产一区二区三区播放-青青草原精品国产亚洲AV-日本黄A级A片国产免费-亚洲精品一区久久久久久-成人18禁在线WWW免费视频

Precocious puberty, a pediatric endocrine disorder classified as central precocious puberty (CPP) or peripheral precocious puberty (PPP), is influenced by diet, gut microbiota, and metabolites, but the specific mechanisms remain unclear. Our study found that increased alpha -diversity and abundance of short -chain fatty acid-producing bacteria led to elevated levels of luteinizing hormone and follicle -stimulating hormone, contributing to precocious puberty. The integration of specific microbiota and metabolites has potential diagnostic value for precocious puberty. The Prevotella genus -controlled interaction factor, influenced by complex carbohydrate consumption, mediated a reduction in estradiol levels. Interactions between obesity -related bacteria and metabolites mediated the beneficial effect of seafood in reducing luteinizing hormone levels, reducing the risk of obesity -induced precocious puberty, and preventing progression from PPP to CPP. This study provides valuable insights into the complex interplay between diet, gut microbiota and metabolites in the onset, development and clinical classification of precocious puberty and warrants further investigation.