caopornx在线超碰免费-欧美亚洲性色影视在线-人妻无码AV一区二区三区-欧美日韩国产一区二区三区播放-青青草原精品国产亚洲AV-日本黄A级A片国产免费-亚洲精品一区久久久久久-成人18禁在线WWW免费视频

論文
您當(dāng)前的位置 :
Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling
論文作者 Ren, GQ; Zhang, YM; Liu, JM; Cheng, WW; Wu, D; Han, MW; Zeng, YY; Zhao, XY; Hu, LN; Zeng, M; Gurram, RK; Hu, XL; Zhou, B; Hou, ZY; Zhu, JF; Jin, WF; Zhong, C
期刊/會(huì)議名稱 DEVELOPMENTAL CELL
論文年度 2024
論文類別
摘要

In mice, skin-resident type 2 innate lymphoid cells (ILC2s) exhibit some ILC3-like characteristics. However, the underlying mechanism remains elusive. Here, we observed lower expression of the ILC2 master regulator GATA3 specifically in cutaneous ILC2s (cILC2s) compared with canonical ILC2s, in line with its functionally divergent role in transcriptional control in cILC2s. Decreased levels of GATA3 enabled the expansion of RORyt fate-mapped (RORytfm+) fm+ ) cILC2s after postnatal days, displaying certain similarities to ILC3s. Single-cell trajectory analysis showed a sequential promotion of the RORytfm+ fm+ cILC2 divergency by RORyt and GATA3. Notably, during hair follicle recycling, these RORytfm+ fm+ cILC2s accumulated around the hair follicle dermal papilla (DP) region to facilitate the process. Mechanistically, we found that GATA3-mediated integrin oc3R1 upregulation on RORytfm+ fm+ cILC2s was required for their positioning around the DP. Overall, our study demonstrates a distinct regulatory role of GATA3 in cILC2s, particularly in promoting the divergence of RORytfm+ fm+ cILC2s to facilitate hair follicle recycling.

14
59
影響因子 10.7
白丝自慰亚洲精品91| 美女日逼精品日b| 红桃精品一区| 日韩成人一卡二卡精品视频| 精品人妻一区二区三区线国色天| 欧美日韩中文精品极品日b| 999久久久韩国精品免费视频| 玖玖久精品国产| 国产精品换脸| 色婷婷日韩精品一区二| aaa级精品无码久久久| 大香蕉98精品在线观看| 日韩精品在线不卡中文| 久久九六精品家庭乱淫| 国产三级精品91| 亚洲精品303| 日韩精品伦理一区二| 成人精品日韩欧美| 欧美精品一品| 国产精品黄AV好吊色| 久热九九这里只有精品一区二区|